GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs943466 | 1 | rs61662306 | chr6:33746697 | LEMD2 | chr6:33738991-33756906:- | 0.25 | 5.07 | 5.68E-7 | Body mass index |
| THCA | cis | rs2129782 | 1 | rs61667532 | chr8:89454997 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs2129782 | 1 | rs61671299 | chr8:89453431 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs2129782 | 1 | rs61683331 | chr8:89455046 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs59374417 | 1 | rs61692996 | chr3:119280368 | ADPRH | chr3:119298523-119308791:+ | -0.22 | -3.51 | 0.000482 | Vitiligo |
| THCA | cis | rs617219 | 1 | rs617219 | chr5:78429594 | BHMT | chr5:78407604-78428112:+ | -0.3 | -5.42 | 9.23E-8 | Betaine levels in individuals undergoing cardiac evaluation |
| THCA | cis | rs617219 | 1 | rs617219 | chr5:78429594 | DMGDH | chr5:78293430-78365449:- | -0.21 | -3.83 | 0.000142 | Betaine levels in individuals undergoing cardiac evaluation |
| THCA | cis | rs617219 | 1 | rs617219 | chr5:78429594 | JMY | chr5:78531954-78623036:+ | -0.17 | -4.72 | 3.03E-6 | Betaine levels in individuals undergoing cardiac evaluation |
| THCA | cis | rs61731371 | 1 | rs61731371 | chr4:186272721 | C4orf47 | chr4:186350545-186370821:+ | -0.28 | -3.43 | 0.000652 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers;3-hydroxypropylmercapturic acid levels in smokers |
| THCA | cis | rs2272306 | 1 | rs61734973 | chr12:53547199 | SOAT2 | chr12:53497274-53518322:+ | -0.22 | -3.55 | 0.000426 | Obesity-related traits |
| THCA | cis | rs9815354 | 1 | rs61744385 | chr3:41756986 | ULK4 | chr3:41288091-42003660:- | 1.04 | 18.65 | 9.55E-59 | Diastolic blood pressure |
| THCA | cis | rs9815354 | 1 | rs61744388 | chr3:41756965 | ULK4 | chr3:41288091-42003660:- | 1.04 | 18.65 | 9.55E-59 | Diastolic blood pressure |
| THCA | cis | rs7551345 | 1 | rs61780780 | chr1:31864183 | ZCCHC17 | chr1:31769842-31837780:+ | -0.31 | -6.02 | 3.47E-9 | Schizophrenia |
| THCA | cis | rs573521 | 1 | rs617819 | chr11:102714716 | MMP1 | chr11:102660641-102668966:- | 0.25 | 4.49 | 8.77E-6 | Cerebrospinal fluid levels of Alzheimer's disease-related proteins |
| THCA | cis | rs2275426 | 1 | rs61783200 | chr1:46297403 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.03 | 1.26E-21 | Body mass index |